Rational, yet simple, design and synthesis of an antifreeze-protein inspired polymer for cellular cryopreservation.
نویسندگان
چکیده
Antifreeze (glyco) proteins AF(G)Ps are potent ice recrystallization inhibitors, which is a desirable property to enhance cryopreservation of donor tissue/cells. Here we present the rational synthesis of a new, biomimetic, ice-recrystallization inhibiting polymer derived from a cheap commodity polymer, based on an ampholyte structure. The polymer is used to enhance the cryopreservation of red blood cells, demonstrating a macromolecular solution to tissue storage.
منابع مشابه
Rational, yet simple, design and synthesis of an antifreeze-protein inspired polymer for cellular cryopreservation† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c5cc04647e Click here for additional data file.
Rational, yet simple, design and synthesis of an antifreezeprotein inspired polymer for cellular cryopreservation Daniel E. Mitchell [b] Neil R. Cameron and Matthew I. Gibson* a Department of Chemistry, University of Warwick, Gibbet Hill Road, Coventry, CV4 7AL, UK. b MOAC DTC, University of Warwick, Gibbet Hill Road, Coventry, CV4 7AL, UK. c Department of Materials Science and Engineering, Mon...
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ورودعنوان ژورنال:
- Chemical communications
دوره 51 65 شماره
صفحات -
تاریخ انتشار 2015